GHK-Cu is a naturally occurring copper-binding tripeptide that regulates over 4,000 genes involved in peptide research, collagen synthesis, and anti-inflammatory responses. 2025-2026 research confirms it delivers bioavailable copper, resets cellular gene expression to a younger-marker state, reduces IL-6/TNF-alpha, supports DNA repair via 84 anti-cancer-related genes, and shows cumulative collagen remodeling with 3-6 months of use.
Research status
clinical investigational
Sequence
Gly-His-Lys
Molecular weight
340.38 Da (free peptide) / 401.93 Da (copper complex)
Molecular formula
C14H24N6O4Cu (copper complex)
For research use only. This summary is a research-scientific overview compiled from peer-reviewed sources. It is not medical advice and is not intended for human or veterinary consumption.
Related products
Third-Party Tested by Verum Analytics
Copper peptide GHK-Cu — the gold standard for collagen synthesis, skin regeneration, and senescence research.
Third-Party Tested by Verum Analytics
Albert's Verdict
GHK-Cu at ≥99% purity does something elegant — it upregulates over 30 genes associated with tissue remodeling while simultaneously downregulating inflammatory markers. The copper chelation is critical; purity here is non-negotiable.
View COA✓ In stock - Ships same day
Arrives as lyophilized (powder) form
Shipped freeze-dried for maximum stability and shelf life. See laboratory preparation guide for handling instructions.
Researchers also added
Research profile
A copper-chelating 3-residue peptide (Gly-His-Lys) that binds Cu²⁺ with high affinity. Characterised in the primary literature as a modulator of DNA gene-expression signatures related to tissue remodelling and copper transport. For laboratory characterisation only.
Molecular formula
C14H24N6O4 · Cu²⁺
Mechanism of action
Binding and functional-assay data for GHK-Cu, from peer-reviewed in-vitro pharmacology publications. Values are receptor activity parameters — not clinical outcomes.
Cu²⁺
Copper(II) binding
High-affinity chelator (in vitro)
GHK-Cu forms a 1:1 copper complex with picomolar affinity, described in the literature as the essential feature underlying subsequent biological activities.
Source: Pickart et al., Biomed Res Int 2015
MMP
Matrix metalloproteinases
Modulator (in vitro)
Dermal fibroblast in-vitro cultures report GHK-Cu-mediated modulation of MMP-1, MMP-2, and TIMP-1/2 expression, implicated in extracellular-matrix remodelling.
Source: Pickart et al., Int J Mol Sci 2018
NRF2
NRF2 antioxidant pathway
Activator (in vitro)
Transcriptomic studies of GHK-Cu-treated fibroblasts describe activation of the NRF2 antioxidant-response pathway.
Source: Pickart et al., Cosmetics 2018
Receptor EC₅₀ values from in-vitro cAMP functional assays reported in peer-reviewed literature. In-vitro / preclinical characterisation only — no clinical or therapeutic claim is expressed or implied. Research use only.
Study framework
Study designs referencing this compound in the published literature. Descriptions cover framework only — phase, participant count, duration, and citation — not outcomes. Click a card to review the source directly.
Wound-healing review
Multi-model dermal and connective tissue review
Pickart et al., Biomed Res Int 2015
Gene-expression profile
Human fibroblast transcriptomic analysis
Hong et al., Mol Cell Biochem 2013
Anti-aging mechanism
Cosmeceutical mechanism review
Pickart et al., Int J Mol Sci 2018
Independent COA
≥99% purity · <0.05 EU/mL endotoxin · lot-specific
Freedom Diagnostic (accredited)
For research use only.
Not for human or veterinary use. All data on this page reflects chemistry attributes, in-vitro pharmacology, and study-framework metadata from published peer-reviewed literature. No statement describes or implies any therapeutic effect in humans. These statements have not been evaluated by the FDA; this product is not intended to diagnose, treat, cure, or prevent any disease. Sold exclusively to qualified researchers and institutions.GHK-Cu is a naturally occurring copper-binding tripeptide that regulates over 4,000 genes involved in peptide research, collagen synthesis, and anti-inflammatory responses. 2025-2026 research confirms it delivers bioavailable copper, resets cellular gene expression to a younger-marker state, reduces IL-6/TNF-alpha, supports DNA repair via 84 anti-cancer-related genes, and shows cumulative collagen remodeling with 3-6 months of use. It has a molecular formula C14H24N6O4Cu (copper complex), mass 340.38 Da (free peptide) / 401.93 Da (copper complex) Da. Its published amino-acid sequence is Gly-His-Lys. Common synonyms in the literature include Copper Peptide GHK, GHK Copper, and Glycyl-L-histidyl-L-lysine copper.
Investigation of GHK-Cu to date is clinical-investigational, with the majority of citations concentrated in animal models and in-vitro assays rather than randomized controlled human trials. Published work referencing GHK-Cu spans Topical wound healing: Extensive research has examined GHK-Cu in dermal wound models, showing effects on reepithelialization, collagen deposition, and wound closure. GHK-Cu superiority over GHK alone has been demonstrated in murine wounds, with effects requiring Cu²⁺ (abolished by chelators like bathocuproine), Skin aging and cosmetic research: Studies have investigated GHK-Cu for effects on photoaging, dermal collagen research, skin thickness, and elasticity. Most human data comes from cosmetic product studies rather than rigorous clinical trials, and Gene expression studies: Microarray analyses have shown GHK-Cu modulates expression of over 4,000 genes, with structural genes upregulated and inflammatory/damaging genes downregulated. Key affected pathways include TGF-β signaling, DNA repair, and antioxidant systems. Proposed mechanisms in the literature include Copper delivery: forms stable complex with Cu²⁺ (binding constant log10 ≈ 16.44), delivering copper while silencing redox toxicity and Gene expression: upregulates structural genes (TGF-β pathway) and downregulates inflammatory genes (IL-6, fibrinogen). None of this material describes therapeutic outcomes in humans, and BioInfinity does not sell, market, or provide dosing guidance for GHK-Cu outside laboratory research.
Lyophilized GHK-Cu arrives as a fluffy off-white solid inside a sealed sterile vial. Because it ships as a lyophilized peptide (340.38 Da (free peptide) / 401.93 Da (copper complex) Da), the powder is best stored between 2–8 °C prior to reconstitution and returned to −20 °C in aliquots for long-term storage post-reconstitution. Reconstitution is typically performed with bacteriostatic water (0.9 % benzyl alcohol preserved) rather than sterile water because the preservative extends solution stability once the vial has been punctured. Warming the reconstituted solution to room temperature before drawing helps redissolve any peptide that has settled against the vial wall. Avoid repeated freeze–thaw cycles: for peptides in this molecular-weight range (340.38 Da (free peptide) / 401.93 Da (copper complex) Da), freeze–thaw stress is one of the most common causes of loss-of-purity between batches.
Every batch of GHK-Cu ships with a batch-specific Certificate of Analysis produced by an ISO-accredited third-party analytical laboratory. Reversed-phase HPLC confirms the assay against the expected 340.38 Da (free peptide) / 401.93 Da (copper complex) Da mass (C14H24N6O4Cu (copper complex)); mass spectrometry validates the exact monoisotopic mass; endotoxin (LAL) testing confirms bacterial-contamination limits appropriate for laboratory research; and residual-solvent panels confirm the manufacturing pipeline. The lot number on the outer label matches the COA on the public /coa-library page — every purity claim is independently verifiable before you open the vial.
For the full mechanistic profile, published references, and constraint notes on GHK-Cu, see the GHK-Cu research page. All references cited on that page are peer-reviewed primary literature.
Research use only. GHK-Cu is sold strictly for in-vitro and animal research. It is not a drug, food, supplement, or cosmetic and is not intended for human or veterinary consumption. No statements on this page describe or imply any therapeutic effect.
Commonly studied alongside in laboratory settings
4 verified buyers
After taking GHK-Cu at the recommended dosage for a couple of months, I honestly didn’t notice any significant difference overall. I didn’t experience any negative side effects or adverse reactions, which was a positive, but I also didn’t see or feel any noticeable improvements. Everyone’s experience may be different, but for me, the results were minimal, and I was left somewhat disappointed after using it consistently for several months.
Easy reconstitution, excellent quality and purity.
Great customer service, great product and speedy delivery!
I was skeptical about ordering online, but product shipped quickly, very well packaged, and the quality seems top tier. Communication was great. Will be using them again for future purchases.
Reviews are submitted by verified buyers via per-order tokenized links. Reviews are evaluated for product-focused content; any review containing therapeutic claims (cured, treats, healed, etc.) may be edited or hidden to maintain compliance with FDA and platform guidelines.
Research Use Only: This product is intended for laboratory research purposes only. Not for human consumption.
