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Bioregulator Compounds

Epithalon (Epitalon)

Name: Epithalon (Epitalon)
Brand: BioInfinity
SKU: epithalon
Availability: InStock
Rating: 5.0 (1 reviews)

AEDG tetrapeptide (Epitalon) — the most-researched telomerase activator for longevity and senescence-focused.

$55.00

99.3% Purity Verified

Third-Party Tested by Verum Analytics• HPLC-UV/MS

Batch: BIL-EPT10-01-2603Mar 7, 2026

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Albert's Verdict

Epithalon's telomerase activation data is what puts it in a category of its own for cellular-aging research. The pineal gland regulation angle adds another layer — this tetrapeptide has more research depth than most compounds three times its size.

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Arrives as lyophilized (powder) form

Shipped freeze-dried for maximum stability and shelf life. See laboratory preparation guide for handling instructions.

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Research profile

Pineal-derived telomerase-modulating tetrapeptide

A synthetic 4-residue peptide (Ala-Glu-Asp-Gly) characterised in the primary literature by the Khavinson group as a modulator of telomerase activity and pineal-gland gene expression in preclinical models. For laboratory characterisation only.

AEDG

NonpolarPolarPositiveNegativeAromaticCys

4-residue schematic

Molecular formula

C14H22N4O9

Molecular weight

390.35 g/mol

Sequence length

4 residues

Physical form

Lyophilized powder

Documented purity

≥99% (HPLC)

Research use onlyPubChem CID 219042 ↗

Mechanism of action

Receptor engagement in the primary literature

Binding and functional-assay data for Epithalon (Epitalon), from peer-reviewed in-vitro pharmacology publications. Values are receptor activity parameters — not clinical outcomes.

TERT

Telomerase reverse transcriptase

Activator (in vitro)

In-vitro human fibroblast cultures report increased TERT expression and telomerase activity following epitalon exposure, sustained over multiple passages.

Source: Khavinson et al., Bull Exp Biol Med 2003

Pineal melatonin pathway

Modulator (in vitro)

Preclinical rodent studies describe epitalon-mediated normalisation of pineal melatonin rhythms, most pronounced in aged animals.

Source: Anisimov et al., Neuroendocrinol Lett 2003

Receptor EC₅₀ values from in-vitro cAMP functional assays reported in peer-reviewed literature. In-vitro / preclinical characterisation only — no clinical or therapeutic claim is expressed or implied. Research use only.

Study framework

Investigational context

Study designs referencing this compound in the published literature. Descriptions cover framework only — phase, participant count, duration, and citation — not outcomes. Click a card to review the source directly.

Telomere length study

In-vitro human fibroblast passages · TERT expression

Khavinson et al., Bull Exp Biol Med 2003

Preclinical geroprotection

Rodent lifespan + tumour-incidence study

Anisimov et al., Ann N Y Acad Sci 2003

Pineal function review

Comparative review of pineal-derived peptides

Khavinson et al., Neuroendocrinol Lett 2002

Independent COA

≥99% purity · <0.05 EU/mL endotoxin · lot-specific

Freedom Diagnostic (accredited)

Cited sources

Peer-reviewed literature

Independent published research indexed from PubMed and peer-reviewed journals — not BioInfinity claims.

[1]PubMed

Epithalon and telomerase activity in human somatic cells

2007 · Bull Exp Biol Med

View source

[2]PubMed

Effect of Epithalamin and Epithalon on cell proliferation and apoptosis

2002 · Bull Exp Biol Med

View source

[3]PubMed

Peptide Epithalon and pineal gland function in aging research

2003 · Neuro Endocrinol Lett

View source

For research use only.

Not for human or veterinary use. All data on this page reflects chemistry attributes, in-vitro pharmacology, and study-framework metadata from published peer-reviewed literature. No statement describes or implies any therapeutic effect in humans. These statements have not been evaluated by the FDA; this product is not intended to diagnose, treat, cure, or prevent any disease. Sold exclusively to qualified researchers and institutions.

Product Description

What Epithalon (Epitalon) is

Epithalon (Epitalon) is a synthetic tetrapeptide (4 amino acids). Epithalon is a synthetic tetrapeptide (AEDG) that activates telomerase via hTERT upregulation. A September 2025 Biogerontology study confirmed dose-dependent telomere extension in normal epithelial, fibroblast, and cancer cell lines. Brunel University (2025) independently replicated telomere lengthening across cell types. Additional 2025 data shows it restores antioxidant genes (SOD2, catalase, HO-1) and prevents DNA hypomethylation in hyperglycemic retinal cells. It has a molecular formula C14H22N4O9, mass 390.35 Da. Its published amino-acid sequence is Ala-Glu-Asp-Gly. Common synonyms in the literature include Epitalon, Epithalone, and AEDG peptide.

What it's studied for

Investigation of Epithalon (Epitalon) to date is primarily preclinical, with the majority of citations concentrated in animal models and in-vitro assays rather than randomized controlled human trials. Published work referencing Epithalon (Epitalon) spans Human cell culture studies: Research in human fetal lung fibroblasts, epithelial cells (HMEC, IBR.3), and lymphocytes has examined Epithalon's effects on telomerase activity and telomere length. Studies using the TRAP (Telomere Repeat Amplification Protocol) assay reported telomere extensions up to 33.3% on average in some lymphocyte studies, Telomerase gene expression: Experiments showed Epithalon upregulates hTERT (the catalytic subunit of telomerase) mRNA expression, with effects occurring primarily during the G1 phase of the cell cycle. The peptide reportedly enters cell nuclei and binds to promoter regions containing ATTTC motifs, and Cancer cell comparisons: In cancer cell lines (21NT, BT474, HeLa), Epithalon was observed to extend telomeres primarily through the ALT (Alternative Lengthening of Telomeres) pathway rather than telomerase activation, suggesting selectivity for healthy cells. This selectivity has been proposed as a safety feature. Proposed mechanisms in the literature include hTERT upregulation: increases telomerase catalytic subunit mRNA expression primarily during G1 cell cycle phase and Chromatin modification: enters cell nuclei, binds promoter regions (ATTTC motifs) for epigenetic activation. None of this material describes therapeutic outcomes in humans, and BioInfinity does not sell, market, or provide dosing guidance for Epithalon (Epitalon) outside laboratory research.

Laboratory handling — storage and reconstitution

Lyophilized Epithalon (Epitalon) arrives as a fluffy off-white solid inside a sealed sterile vial. Because it ships as a lyophilized peptide (390.35 Da), the powder is best stored between 2–8 °C prior to reconstitution and returned to −20 °C in aliquots for long-term storage post-reconstitution. Reconstitution is typically performed with bacteriostatic water (0.9 % benzyl alcohol preserved) rather than sterile water because the preservative extends solution stability once the vial has been punctured. Warming the reconstituted solution to room temperature before drawing helps redissolve any peptide that has settled against the vial wall. Avoid repeated freeze–thaw cycles: for peptides in this molecular-weight range (390.35 Da), freeze–thaw stress is one of the most common causes of loss-of-purity between batches.

How this batch is verified

Every batch of Epithalon (Epitalon) ships with a batch-specific Certificate of Analysis produced by an ISO-accredited third-party analytical laboratory. Reversed-phase HPLC confirms the assay against the expected 390.35 Da mass (C14H22N4O9); mass spectrometry validates the exact monoisotopic mass; endotoxin (LAL) testing confirms bacterial-contamination limits appropriate for laboratory research; and residual-solvent panels confirm the manufacturing pipeline. The lot number on the outer label matches the COA on the public /coa-library page — every purity claim is independently verifiable before you open the vial.

Related research

For the full mechanistic profile, published references, and constraint notes on Epithalon (Epitalon), see the Epithalon (Epitalon) research page. All references cited on that page are peer-reviewed primary literature.

Research use only. Epithalon (Epitalon) is sold strictly for in-vitro and animal research. It is not a drug, food, supplement, or cosmetic and is not intended for human or veterinary consumption. No statements on this page describe or imply any therapeutic effect.

Technical Specifications

Molecular Formula: C14H22N4O9
Molecular Weight: 390.35 g/mol
Sequence: Ala-Glu-Asp-Gly

Customer Reviews

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1 week ago

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6 weeks ago

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4 weeks ago

Detailed documentation included

Love that they include full documentation with every order. The third-party testing gives me confidence in what I'm buying.

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2 months ago

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Compared prices across multiple suppliers. BioInfinity has the best combination of quality and price. The bulk discounts are a nice bonus.

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Frequently Researched Together

Commonly studied alongside in laboratory settings

Bundle total (3 items):$117.00

Research FAQ — Epithalon (Epitalon)

Frequently asked questions about this compound for laboratory researchers.

What is Epithalon?+

Epithalon (Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) originally derived from the bovine pineal extract Epithalamin. Published research investigates its effects on telomerase activity, pineal-axis signaling, and aging-related models in rodents and cell culture.

Cited: PMID 17298874, PMID 11788859

What does Epithalon research literature describe regarding telomerase?+

The 2007 publication in Bull Exp Biol Med reports observed increases in telomerase activity in human somatic-cell research models exposed to Epithalon. Researchers should refer to the cited paper for methodology and limitations.

Cited: PMID 17298874

How is Epithalon dosed in published research?+

Animal and cell-culture studies cite a wide concentration range. Researchers should consult the cited literature and their IRB-approved protocol; BioInfinity does not provide human dosing guidance.

How is Epithalon stored?+

Lyophilized at −20 °C; reconstituted held at 2–8 °C and used within 30 days. Refer to COA.

Published research references

Peer-reviewed literature relevant to Epithalon (Epitalon) research. Linked PubMed IDs open the original source.

[1]Epithalon and telomerase activity in human somatic cells — Bull Exp Biol Med (2007) · PMID 17298874
[2]Effect of Epithalamin and Epithalon on cell proliferation and apoptosis — Bull Exp Biol Med (2002) · PMID 11788859
[3]Peptide Epithalon and pineal gland function in aging research — Neuro Endocrinol Lett (2003) · PMID 15622116

Reviewed by the BioInfinity Research Team

Content reviewed by our research and quality team — biochemistry-degreed reviewers working alongside our analytical lab partner (Janoshik Analytical). Every product page is cross-checked against the cited peer-reviewed literature and the current batch's third-party COA.

For laboratory research use only. Not for human or veterinary use. Content is informational and does not constitute medical advice.

Verified reviews — Epithalon (Epitalon)

1 verified buyer

★★★★★

5.0 / 5

Joshua E.Verified buyer

Jun 20, 2026

★★★★★

Pure and fast

Works as intended!

Reviews are submitted by verified buyers via per-order tokenized links. Reviews are evaluated for product-focused content; any review containing therapeutic claims (cured, treats, healed, etc.) may be edited or hidden to maintain compliance with FDA and platform guidelines.

Learn More About This Peptide

Epithalon Research Summary →Browse All Peptide Research →Research Guides & Protocols

Research Use Only: This product is intended for laboratory research purposes only. Not for human consumption.

Research summary

Epithalon (Epitalon) — clinical & mechanistic profile

Epithalon is a synthetic tetrapeptide (AEDG) that activates telomerase via hTERT upregulation. A September 2025 Biogerontology study confirmed dose-dependent telomere extension in normal epithelial, fibroblast, and cancer cell lines. Brunel University (2025) independently replicated telomere lengthening across cell types. Additional 2025 data shows it restores antioxidant genes (SOD2, catalase, HO-1) and prevents DNA hypomethylation in hyperglycemic retinal cells.

Research status

preclinical

Sequence

Ala-Glu-Asp-Gly

Molecular weight

390.35 Da

Molecular formula

C14H22N4O9

Studied applications

•Telomerase activation: upregulates hTERT mRNA, activating telomerase during G1 cell cycle phase via TRAP protocol confirmation
•Telomere elongation: extends telomeres approximately 33.3% in somatic cells, increases proliferative potential beyond Hayflick limit
•Cell lifespan extension: treated fetal fibroblasts reached 44+ passages vs. 34 for controls
•Histone H1 binding: binds H1.3 and H1.6 variants, potentially triggering ALT pathways via H19 derepression
•Anti-tumor effects: reduces spontaneous tumors and metastases in mice; inhibits MMP9 in aging skin fibroblasts

Mechanisms of action

•hTERT upregulation: increases telomerase catalytic subunit mRNA expression primarily during G1 cell cycle phase
•Chromatin modification: enters cell nuclei, binds promoter regions (ATTTC motifs) for epigenetic activation
•Histone H1 binding: binds H1.3 and H1.6 variants, potentially inhibiting telomere stability proteins
•Cancer cell selectivity: in telomerase-positive cancer cells, may trigger ALT pathway via H19 derepression rather than direct telomerase activation
•Pineal gland modulation: influences melatonin synthesis pathways; derived from epithalamin (bovine pineal extract)
•Heterochromatin effects: causes heterochromatin decondensation in elderly lymphocytes

Research constraints & safety notes

•Most research originates from a limited number of research groups (primarily Russian)
•Limited independent replication in Western research institutions
•No FDA-approved human applications or completed Phase 3 trials
•Telomerase activation in humans not confirmed in rigorous clinical trials
•Long-term safety of telomerase activation uncertain (theoretical cancer concerns)

Peer-reviewed references

Khavinson VK — Epithalamin telomerase activation research (2003)PMID: 12937225View
Khavinson VK — Peptide bioregulation of aging (2003)PMID: 14501183View
Anisimov VN — Peptide geroprotector studiesPMID: 16706657View
Telomere elongation in human somatic cellsPMID: 11524632View
PMC12411320 — Epithalon histone H1 binding and ALT pathway mechanisms (2024)

Read the full Epithalon (Epitalon) research page View public COA library

For research use only. This summary is a research-scientific overview compiled from peer-reviewed sources. It is not medical advice and is not intended for human or veterinary consumption.

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